The Great Lakes region is considered a likely climate change haven based on its supply of fresh water and relative shelter from Sea change, fires, and hurricanes.
San Diego to Great Lakes region:
Detroit (4:30 hrs)
Chicago (4:15 hr)
Cleveland (4:15 hrs)
Minneapolis (3:51 hrs) (MSP)
Duluth, MN:
From Chicago ~7 hours by car
From SAN 6h2mins via MSP